Aberrant plasticity of peripheral sensory axons in a painful neuropathy

Sci Rep. 2017 Jun 13;7(1):3407. doi: 10.1038/s41598-017-03390-9.

Abstract

Neuronal cells express considerable plasticity responding to environmental cues, in part, through subcellular mRNA regulation. Here we report on the extensive changes in distribution of mRNAs in the cell body and axon compartments of peripheral sensory neurons and the 3' untranslated region (3'UTR) landscapes after unilateral sciatic nerve entrapment (SNE) injury in rats. Neuronal cells dissociated from SNE-injured and contralateral L4 and L5 dorsal root ganglia were cultured in a compartmentalized system. Axonal and cell body RNA samples were separately subjected to high throughput RNA sequencing (RNA-Seq). The injured axons exhibited enrichment of mRNAs related to protein synthesis and nerve regeneration. Lengthening of 3'UTRs was more prevalent in the injured axons, including the newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA. Alternative polyadenylation was largely independent from the relative abundance of axonal mRNAs; but they were highly clustered in functional pathways related to RNA granule formation in the injured axons. These RNA-Seq data analyses indicate that peripheral nerve injury may result in highly selective mRNA enrichment in the affected axons with 3'UTR alterations potentially contributing to the mechanism of neuropathic pain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / pathology*
  • Cells, Cultured
  • Ganglia, Spinal / metabolism
  • Ganglia, Spinal / pathology*
  • Genetic Markers*
  • High-Throughput Nucleotide Sequencing
  • Male
  • Nerve Regeneration
  • Peripheral Nerve Injuries / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Neuropathy / genetics
  • Sciatic Neuropathy / pathology*
  • Sensory Receptor Cells / metabolism
  • Sensory Receptor Cells / pathology*

Substances

  • Genetic Markers