SnapShot: Phosphoregulation of Mitosis

Andrew Burgess; Jenny Vuong; Samuel Rogers; Marcos Malumbres; Seán I O'Donoghue

doi:10.1016/j.cell.2017.06.003

SnapShot: Phosphoregulation of Mitosis

Cell. 2017 Jun 15;169(7):1358-1358.e1. doi: 10.1016/j.cell.2017.06.003.

Authors

Andrew Burgess¹, Jenny Vuong², Samuel Rogers³, Marcos Malumbres⁴, Seán I O'Donoghue⁵

Affiliations

¹ Garvan Institute of Medical Research, Sydney NSW 2010, Australia; St. Vincent's Clinical School, UNSW, Sydney NSW 2010, Australia.
² Data61, CSIRO, Sydney NSW 2015, Australia.
³ Garvan Institute of Medical Research, Sydney NSW 2010, Australia.
⁴ Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
⁵ Garvan Institute of Medical Research, Sydney NSW 2010, Australia; Data61, CSIRO, Sydney NSW 2015, Australia.

PMID: 28622516
DOI: 10.1016/j.cell.2017.06.003

Abstract

During mitosis, a cell divides its duplicated genome into two identical daughter cells. This process must occur without errors to prevent proliferative diseases (e.g., cancer). A key mechanism controlling mitosis is the precise timing of more than 32,000 phosphorylation and dephosphorylation events by a network of kinases and counterbalancing phosphatases. The identity, magnitude, and temporal regulation of these events have emerged recently, largely from advances in mass spectrometry. Here, we show phosphoevents currently believed to be key regulators of mitosis. For an animated version of this SnapShot, please see http://www.cell.com/cell/enhanced/odonoghue2.

MeSH terms

Animals
Humans
Mitosis*
Phosphorylation
Protein Kinases / metabolism*

Substances

Protein Kinases