Inhibition of [3H] glutamate release from rat hippocampal slices by L-phenylisopropyladenosine

Acta Physiol Scand. 1985 Sep;125(1):121-3. doi: 10.1111/j.1748-1716.1985.tb07698.x.

Abstract

Hippocampal slices were labelled with [3H]glutamate. Evoked release, which was calcium-dependent and inhibited by tetrodotoxin, could be reduced concentration-dependently by L-PIA. The effect of L-PIA was blocked by 10 microM 8-phenyltheophylline. The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Animals
  • Calcium / pharmacology
  • Glutamates / metabolism*
  • Glutamic Acid
  • Hippocampus / drug effects*
  • In Vitro Techniques
  • Male
  • Phenylisopropyladenosine / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Tetrodotoxin / pharmacology
  • Theophylline / analogs & derivatives
  • Theophylline / pharmacology

Substances

  • Glutamates
  • Phenylisopropyladenosine
  • Glutamic Acid
  • Tetrodotoxin
  • Theophylline
  • 8-phenyltheophylline
  • Adenosine
  • Calcium