Abstract
Hippocampal slices were labelled with [3H]glutamate. Evoked release, which was calcium-dependent and inhibited by tetrodotoxin, could be reduced concentration-dependently by L-PIA. The effect of L-PIA was blocked by 10 microM 8-phenyltheophylline. The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives*
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Animals
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Calcium / pharmacology
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Glutamates / metabolism*
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Glutamic Acid
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Hippocampus / drug effects*
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In Vitro Techniques
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Male
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Phenylisopropyladenosine / pharmacology*
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Rats
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Rats, Inbred Strains
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Tetrodotoxin / pharmacology
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Theophylline / analogs & derivatives
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Theophylline / pharmacology
Substances
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Glutamates
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Phenylisopropyladenosine
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Glutamic Acid
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Tetrodotoxin
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Theophylline
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8-phenyltheophylline
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Adenosine
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Calcium