Pneumococcal vaccine prevents death from acute lower-respiratory-tract infections in Papua New Guinean children

Lancet. 1986 Oct 18;2(8512):877-81. doi: 10.1016/s0140-6736(86)90409-5.

Abstract

In three double-blind placebo-controlled trials of pneumococcal capsular polysaccharide vaccines against death from acute lower-respiratory-tract infections (ALRI), children were vaccinated at 6 months to 5 years of age. The efficacy of the vaccines against ALRI as the sole cause of death was estimated at 59% in children vaccinated when younger than 5 years (p = 0.008) and 50% in children vaccinated when younger than 2 years (p = 0.043). Mortality from all causes was 19% less in the vaccinated group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Bacterial Vaccines*
  • Child, Preschool
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Immunization Schedule
  • Infant
  • Papua New Guinea
  • Pneumococcal Vaccines
  • Random Allocation
  • Respiratory Tract Infections / mortality*
  • Respiratory Tract Infections / prevention & control
  • Streptococcus pneumoniae / immunology*

Substances

  • Bacterial Vaccines
  • Pneumococcal Vaccines