Genomic imprinting beyond DNA methylation: a role for maternal histones

Courtney W Hanna; Gavin Kelsey

doi:10.1186/s13059-017-1317-9

Genomic imprinting beyond DNA methylation: a role for maternal histones

Genome Biol. 2017 Sep 19;18(1):177. doi: 10.1186/s13059-017-1317-9.

Authors

Courtney W Hanna^{1

2}, Gavin Kelsey^{3

4}

Affiliations

¹ Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.
² Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.
³ Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. Gavin.Kelsey@babraham.ac.uk.
⁴ Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. Gavin.Kelsey@babraham.ac.uk.

Abstract

Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also confer imprinting.

Publication types

Review
Comment

MeSH terms

Animals
Chromatin / genetics
Chromatin / metabolism
DNA Methylation
Gene Expression Regulation, Developmental
Genomic Imprinting*
Histone Code*
Humans

Substances

Chromatin

Grants and funding

MR/K011332/1/MRC_/Medical Research Council/United Kingdom