Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures

Jessica R Allegretti; Andrew S Allegretti; Emmalee Phelps; Huiping Xu; Monika Fischer; Zain Kassam

doi:10.1016/j.cgh.2017.10.031

Classifying Fecal Microbiota Transplantation Failure: An Observational Study Examining Timing and Characteristics of Fecal Microbiota Transplantation Failures

Clin Gastroenterol Hepatol. 2018 Nov;16(11):1832-1833. doi: 10.1016/j.cgh.2017.10.031. Epub 2017 Nov 16.

Authors

Jessica R Allegretti¹, Andrew S Allegretti², Emmalee Phelps³, Huiping Xu⁴, Monika Fischer³, Zain Kassam⁵

Affiliations

¹ Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address: jallegretti@partners.org.
² Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts.
³ Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, Indiana.
⁴ Department of Biostatistics, The Richard M. Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, Indiana.
⁵ OpenBiome, Somerville, Massachusetts; Massachusetts Institute of Technology, Cambridge, Massachusetts.

PMID: 29104129
DOI: 10.1016/j.cgh.2017.10.031

Abstract

Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (rCDI), with cure rates higher than 80%.^1-3 FMT failure is defined as diarrhea and a positive stool laboratory test for C difficile at any point during the 8-week follow-up period after FMT.⁴.

Publication types

Observational Study

MeSH terms

Adult
Aged
Aged, 80 and over
Clostridioides difficile / isolation & purification*
Clostridium Infections / therapy*
Fecal Microbiota Transplantation*
Feces / microbiology*
Female
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Treatment Failure
Young Adult