The importance of the circadian system & sleep for bone health

Christine M Swanson; Wendy M Kohrt; Orfeu M Buxton; Carol A Everson; Kenneth P Wright Jr; Eric S Orwoll; Steven A Shea

doi:10.1016/j.metabol.2017.12.002

The importance of the circadian system & sleep for bone health

Metabolism. 2018 Jul:84:28-43. doi: 10.1016/j.metabol.2017.12.002. Epub 2017 Dec 9.

Authors

Christine M Swanson¹, Wendy M Kohrt², Orfeu M Buxton³, Carol A Everson⁴, Kenneth P Wright Jr⁵, Eric S Orwoll⁶, Steven A Shea⁷

Affiliations

¹ Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Christine.Swanson@UCDenver.edu.
² Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Eastern Colorado VA Geriatric, Research, Education, and Clinical Center, Aurora, CO, USA.
³ Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Sleep Health Institute, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Social and Behavioral Sciences, Harvard Chan School of Public Health, Boston, MA, USA.
⁴ Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI, USA.
⁵ Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
⁶ Division of Endocrinology and Bone and Mineral Unit, Oregon Health & Science University, Portland, OR, USA.
⁷ Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA; OHSU-PSU School of Public Health, Portland, OR, USA.

Abstract

Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

Keywords: Bone; Bone turnover; Circadian; Fracture; Sleep.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Bone Density / physiology
Bone and Bones / physiology*
Circadian Clocks / physiology
Circadian Rhythm / physiology*
Health
Humans
Sleep / physiology*
Sleep Deprivation / complications
Sleep Deprivation / metabolism
Sleep Deprivation / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding