Toxicity of long-term use of proton pump inhibitors in children

Pauline De Bruyne; Shinya Ito

doi:10.1136/archdischild-2017-314026

Toxicity of long-term use of proton pump inhibitors in children

Arch Dis Child. 2018 Jan;103(1):78-82. doi: 10.1136/archdischild-2017-314026.

Authors

Pauline De Bruyne¹, Shinya Ito^{2

3}

Affiliations

¹ Department of Paediatrics and Medical Genetics, Ghent University, Gent, Belgium.
² Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
³ Department of Paediatrics and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

PMID: 29237614
DOI: 10.1136/archdischild-2017-314026

Abstract

Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B₁₂ deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children.

Keywords: adverse events; children; gastroesophageal reflux; proton pump inhibitors; safety.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Child
Gastroesophageal Reflux / drug therapy*
Humans
Proton Pump Inhibitors / adverse effects*
Risk

Substances

Proton Pump Inhibitors