Abstract
We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35 °C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric oxide synthase inhibition. These results suggest a functional role of P2 receptors in the regulation of cutaneous vascular tone during ambient heat exposure at rest.
Keywords:
ATP; heat loss; microcirculation; perte de chaleur.
MeSH terms
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Adult
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Cross-Over Studies
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Enzyme Inhibitors / pharmacology
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Exercise / physiology*
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Hot Temperature
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Humans
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Male
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NG-Nitroarginine Methyl Ester / administration & dosage
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NG-Nitroarginine Methyl Ester / pharmacology*
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Purinergic P2 Receptor Antagonists*
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Pyridoxine / administration & dosage
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Pyridoxine / pharmacology*
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Rest / physiology*
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Skin Physiological Phenomena / drug effects
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Vasodilation / drug effects*
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Vitamin B Complex / pharmacology
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Young Adult
Substances
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Enzyme Inhibitors
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Purinergic P2 Receptor Antagonists
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Vitamin B Complex
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Pyridoxine
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NG-Nitroarginine Methyl Ester