Autoimmunity and autoimmune co-morbidities in psoriasis

Immunology. 2018 May;154(1):21-27. doi: 10.1111/imm.12891. Epub 2018 Feb 6.

Abstract

Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor-α/interleukin-23/interleukin-17 axis is now known to be the major mechanism in the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is co-morbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune co-morbidities in psoriasis.

Keywords: alopecia; autoimmunity; bullous pemphigoid; psoriasis; thyroiditis; vitiligo.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / metabolism
  • Autoimmunity*
  • Comorbidity
  • Humans
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism
  • Interleukin-23 / immunology
  • Interleukin-23 / metabolism
  • Lymphocyte Activation
  • Psoriasis / epidemiology
  • Psoriasis / immunology*
  • Psoriasis / metabolism
  • Signal Transduction
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Interleukin-17
  • Interleukin-23
  • Tumor Necrosis Factor-alpha