Hypersexuality associated with paliperidone

Exp Clin Psychopharmacol. 2018 Apr;26(2):109-112. doi: 10.1037/pha0000178. Epub 2018 Feb 1.

Abstract

We report a case of unusual sexual symptoms in a 43-year-old female patient with schizophrenia (according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition), who was being treated with a depot formulation of paliperidone palmitate, an atypical antipsychotic medication. The symptoms included increased sexual desire, sexual preoccupation, constant drive for intercourse, and sexual arousal with unrelated stimuli such as urination. Potential neurochemical mechanisms have been elucidated for this symptomatology. Paliperidone palmitate has broad neuropharmacological effects, which might have contributed to the development of this rare clinical condition. (PsycINFO Database Record

MeSH terms

  • Adult
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / pharmacokinetics
  • Delayed-Action Preparations
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Humans
  • Male
  • Paliperidone Palmitate* / administration & dosage
  • Paliperidone Palmitate* / adverse effects
  • Paliperidone Palmitate* / pharmacokinetics
  • Peripheral Nervous System Agents
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy*
  • Sexual Behavior / drug effects*

Substances

  • Antipsychotic Agents
  • Delayed-Action Preparations
  • Peripheral Nervous System Agents
  • Paliperidone Palmitate