The Human Gut Microbiome: From Association to Modulation

Thomas S B Schmidt; Jeroen Raes; Peer Bork

doi:10.1016/j.cell.2018.02.044

The Human Gut Microbiome: From Association to Modulation

Cell. 2018 Mar 8;172(6):1198-1215. doi: 10.1016/j.cell.2018.02.044.

Authors

Thomas S B Schmidt¹, Jeroen Raes², Peer Bork³

Affiliations

¹ European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
² KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute, Herestraat 49, 3000 Leuven, Belgium; VIB, Center for Microbiology, Heerestraat 49, 3000 Leuven, Belgium. Electronic address: jeroen.raes@kuleuven.vib.be.
³ European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, 69120 Heidelberg, Germany; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany; Department of Bioinformatics, Biocenter, University of Würzburg, 97074 Würzburg, Germany. Electronic address: bork@embl.de.

PMID: 29522742
DOI: 10.1016/j.cell.2018.02.044

Abstract

Our understanding of the human gut microbiome continues to evolve at a rapid pace, but practical application of thisknowledge is still in its infancy. This review discusses the type of studies that will be essential for translating microbiome research into targeted modulations with dedicated benefits for the human host.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Disease
Gastrointestinal Microbiome / physiology*
Gastrointestinal Tract / metabolism*
Gastrointestinal Tract / microbiology*
Health Status
Host Microbial Interactions*
Humans
Metabolomics / methods
Research / trends