Recent trends in the structural revision of natural products

Nat Prod Rep. 2018 Jun 20;35(6):514-531. doi: 10.1039/c8np00011e.

Abstract

Covering: 2012 to 2017 This article reviews recent reports on the structural revision of natural products. Through a critical assessment of the original and revised published structures, the article addresses why each structure was targeted for revision, discusses the techniques and key discrepancies that led to the proposal of the revised structure, and offers measures that may have been taken during the original structure determination to prevent error. With the revised structures in hand, weaknesses of original proposals are assessed, providing a better understanding on the logic behind structure determination.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biological Products / chemistry*
  • Crystallography, X-Ray*
  • Magnetic Resonance Spectroscopy*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Biological Products