Altered Cellular Metabolism Drives Trained Immunity

Yahya Sohrabi; Rinesh Godfrey; Hannes M Findeisen

doi:10.1016/j.tem.2018.03.012

Altered Cellular Metabolism Drives Trained Immunity

Trends Endocrinol Metab. 2018 Sep;29(9):602-605. doi: 10.1016/j.tem.2018.03.012. Epub 2018 Apr 5.

Authors

Yahya Sohrabi¹, Rinesh Godfrey², Hannes M Findeisen³

Affiliations

¹ Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany. Electronic address: Yahya.Sohrabi@ukmuenster.de.
² Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.
³ Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany. Electronic address: Hannes.Findeisen@ukmuenster.de.

PMID: 29627292
DOI: 10.1016/j.tem.2018.03.012

Abstract

Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

Keywords: HSPCs; epigenetics; immunometabolism; monocytes/macrophages; trained immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Epigenesis, Genetic / immunology*
Hematopoietic Stem Cells / metabolism*
Humans
Immunity, Innate / immunology*
Monocytes / metabolism*