Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing

Guangwu Guo; Noopur S Raje; Charles Seifer; Jake Kloeber; Randi Isenhart; Gavin Ha; Andrew J Yee; Elizabeth K O'Donnell; Yu-Tzu Tai; Paul G Richardson; Giada Bianchi; Jacob P Laubach; Diane Warren; Erica Gemme; Jordan Voisine; Julia Frede; Antonis Kokkalis; Huiyoung Yun; Valeriya Dimitrova; Tushara Vijaykumar; Matthew Meyerson; Nikhil C Munshi; Kenneth C Anderson; Birgit Knoechel; Jens G Lohr

doi:10.1038/s41375-018-0115-z

Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing

Leukemia. 2018 Aug;32(8):1838-1841. doi: 10.1038/s41375-018-0115-z. Epub 2018 Mar 27.

Authors

Guangwu Guo^{1

2

3}, Noopur S Raje^{4

5}, Charles Seifer^{1

2

3}, Jake Kloeber^{1

2

3}, Randi Isenhart^{1

2

3}, Gavin Ha^{1

3}, Andrew J Yee^{4

5}, Elizabeth K O'Donnell^{4

5}, Yu-Tzu Tai^{1

4}, Paul G Richardson^{1

4

6}, Giada Bianchi^{1

4

6}, Jacob P Laubach^{1

4

6}, Diane Warren^{1

4}, Erica Gemme⁵, Jordan Voisine^{1

2

3}, Julia Frede^{1

2

3}, Antonis Kokkalis^{1

2

3}, Huiyoung Yun^{1

2

3}, Valeriya Dimitrova^{1

2

3}, Tushara Vijaykumar^{1

2

3}, Matthew Meyerson^{1

3

4

7

8}, Nikhil C Munshi^{1

4

6}, Kenneth C Anderson^{1

4

6}, Birgit Knoechel^{2

3

4}, Jens G Lohr^{9

10

11

12}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
³ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Harvard Medical School, Boston, MA, USA.
⁵ Center for Multiple Myeloma, Massachusetts General Hospital, Boston, MA, USA.
⁶ Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA, USA.
⁷ Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁸ Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
⁹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. jensg_lohr@dfci.harvard.edu.
¹⁰ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. jensg_lohr@dfci.harvard.edu.
¹¹ Broad Institute of MIT and Harvard, Cambridge, MA, USA. jensg_lohr@dfci.harvard.edu.
¹² Harvard Medical School, Boston, MA, USA. jensg_lohr@dfci.harvard.edu.

No abstract available

Publication types

Randomized Controlled Trial

MeSH terms

Biomarkers, Tumor / genetics*
Case-Control Studies
Cell-Free Nucleic Acids / analysis*
Cell-Free Nucleic Acids / genetics
Clonal Evolution*
Exome Sequencing / methods*
Follow-Up Studies
Humans
Multiple Myeloma / genetics*
Multiple Myeloma / pathology*
Sequence Analysis, DNA / methods
Whole Genome Sequencing / methods*

Substances

Biomarkers, Tumor
Cell-Free Nucleic Acids

Publication types

MeSH terms

Substances

Grants and funding