Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate

CNS Spectr. 2018 Jun;23(3):187-191. doi: 10.1017/S1092852918001013.

Abstract

Psychosis is now widely hypothesized to involve neural networks beyond the classical dopaminergic mesolimbic pathway, including serotonin and glutamate systems as well.

Publication types

  • Review

MeSH terms

  • Brain / metabolism
  • Brain / physiopathology
  • Dopamine / metabolism*
  • Glutamic Acid / metabolism*
  • Humans
  • Psychotic Disorders / etiology
  • Psychotic Disorders / metabolism*
  • Psychotic Disorders / physiopathology
  • Schizophrenia / complications
  • Schizophrenia / metabolism*
  • Schizophrenia / physiopathology
  • Serotonin / metabolism*
  • Synaptic Transmission*

Substances

  • Serotonin
  • Glutamic Acid
  • Dopamine