Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Viral / cerebrospinal fluid
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Antigens, Viral / immunology*
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B-Lymphocytes / immunology*
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Brain / immunology
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Brain / pathology
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Child
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Child, Preschool
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Encephalitis Virus, Japanese / immunology
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Encephalitis, Japanese / immunology*
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Encephalitis, Japanese / pathology
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Humans
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Immunoenzyme Techniques
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Immunoglobulin G / cerebrospinal fluid
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Immunoglobulin M / cerebrospinal fluid
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Infant
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Macrophages / immunology
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Phagocytosis
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T-Lymphocytes / immunology*
Substances
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Antibodies, Viral
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Antigens, Viral
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Immunoglobulin G
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Immunoglobulin M