3D bioprinting for cardiovascular regeneration and pharmacology

Haitao Cui; Shida Miao; Timothy Esworthy; Xuan Zhou; Se-Jun Lee; Chengyu Liu; Zu-Xi Yu; John P Fisher; Muhammad Mohiuddin; Lijie Grace Zhang

doi:10.1016/j.addr.2018.07.014

3D bioprinting for cardiovascular regeneration and pharmacology

Adv Drug Deliv Rev. 2018 Jul:132:252-269. doi: 10.1016/j.addr.2018.07.014. Epub 2018 Jul 24.

Authors

Affiliations

¹ Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
² National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
³ Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD 20742, USA.
⁴ Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.
⁵ Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA. Electronic address: lgzhang@gwu.edu.

Abstract

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of the most advanced techniques for creating complicated cardiovascular implants with biomimetic features, which are capable of recapitulating both the native physiochemical and biomechanical characteristics of the cardiovascular system. The present review provides an overview of the cardiovascular system, as well as describes the principles of, and recent advances in, 3D bioprinting cardiovascular tissues and models. Moreover, this review will focus on the applications of 3D bioprinting technology in cardiovascular repair/regeneration and pharmacological modeling, further discussing current challenges and perspectives.

Keywords: 3D bioprinting; Cardiac tissue; Cardiovascular; Myocardium; Pharmacology; Regeneration; Tissue model; Valves; Vasculature.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Biomimetic Materials / chemistry
Bioprinting*
Cardiovascular System / anatomy & histology*
Cardiovascular System / cytology
Cardiovascular System / drug effects*
Humans
Printing, Three-Dimensional*
Regeneration*
Tissue Engineering

Grants and funding

DP2 EB020549/EB/NIBIB NIH HHS/United States