Choices in vaccine trial design in epidemics of emerging infections

PLoS Med. 2018 Aug 7;15(8):e1002632. doi: 10.1371/journal.pmed.1002632. eCollection 2018 Aug.

Abstract

In a Policy Forum, Marc Lipsitch and colleagues discuss trial design issues in infectious disease outbreaks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Communicable Diseases, Emerging / epidemiology
  • Communicable Diseases, Emerging / prevention & control*
  • Double-Blind Method
  • Drugs, Investigational / therapeutic use*
  • Ebola Vaccines / therapeutic use
  • Epidemics*
  • Ethics, Research
  • Feasibility Studies
  • Hemorrhagic Fever, Ebola / epidemiology
  • Hemorrhagic Fever, Ebola / prevention & control
  • Humans
  • Placebos
  • Randomized Controlled Trials as Topic / ethics
  • Randomized Controlled Trials as Topic / methods*
  • Research Design
  • Vaccines / therapeutic use*

Substances

  • Drugs, Investigational
  • Ebola Vaccines
  • Placebos
  • Vaccines