Vitamin D in SLE: a role in pathogenesis and fatigue? A review of the literature

M H Nguyen; K Bryant; S G O'Neill

doi:10.1177/0961203318796293

Vitamin D in SLE: a role in pathogenesis and fatigue? A review of the literature

Lupus. 2018 Nov;27(13):2003-2011. doi: 10.1177/0961203318796293. Epub 2018 Aug 29.

Authors

M H Nguyen^{1

2}, K Bryant², S G O'Neill^{1

2}

Affiliations

¹ 1 Rheumatology Department, Liverpool Hospital, Australia.
² 2 SWS Clinical School, University of New South Wales, and the Ingham Institute for Applied Medical Research, Australia.

PMID: 30157716
DOI: 10.1177/0961203318796293

Abstract

Fatigue is a common, disabling problem that is highly prevalent in patients with systemic lupus erythematous (SLE). More recently, vitamin D status has been established as a potential contributor to SLE pathogenesis and manifestations, in particular fatigue. This review summarizes the literature regarding the role of vitamin D in SLE, and provides an overview of the recent literature examining the association between vitamin D and fatigue in patients with SLE. Finally, the role of vitamin D supplementation in the treatment of SLE-related fatigue is considered.

Keywords: Systemic lupus erythematosus; fatigue; vitamin D.

Publication types

Review

MeSH terms

Dietary Supplements
Fatigue / drug therapy
Fatigue / etiology*
Humans
Lupus Erythematosus, Systemic / complications*
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Treatment Outcome
Vitamin D / physiology*
Vitamin D / therapeutic use
Vitamin D Deficiency / complications*
Vitamin D Deficiency / drug therapy

Substances

Vitamin D