Pour Some Sugar on TDP(-43)

Steven Boeynaems; Aaron D Gitler

doi:10.1016/j.molcel.2018.08.032

Pour Some Sugar on TDP(-43)

Mol Cell. 2018 Sep 6;71(5):649-651. doi: 10.1016/j.molcel.2018.08.032.

Authors

Steven Boeynaems¹, Aaron D Gitler²

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.

PMID: 30193092
DOI: 10.1016/j.molcel.2018.08.032

Abstract

In this issue of Molecular Cell, McGurk et al. (2018) identify how poly(ADP-ribose) binding tunes the phase behavior of the ALS disease protein TDP-43, uncovering the molecular events underlying its aggregation in disease and illuminating a novel therapeutic target.

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MeSH terms

Amyotrophic Lateral Sclerosis*
DNA-Binding Proteins
Humans
Poly Adenosine Diphosphate Ribose*
Sugars

Substances

DNA-Binding Proteins
Sugars
TARDBP protein, human
Poly Adenosine Diphosphate Ribose