Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India

Jayshree Advani; Kusum Sharma; Renu Verma; Oishi Chatterjee; Hitendra S Solanki; Aman Sharma; Subhash Varma; Manish Modi; Pallab Ray; Megha Sharma; M S Dhillion; Akhilesh Pandey; Harsha Gowda; T S Keshava Prasad

doi:10.1016/j.dib.2018.08.048

Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India

Data Brief. 2018 Aug 24:20:617-622. doi: 10.1016/j.dib.2018.08.048. eCollection 2018 Oct.

Authors

Jayshree Advani^{1

2}, Kusum Sharma³, Renu Verma¹, Oishi Chatterjee^{1

4

5}, Hitendra S Solanki^{1

6}, Aman Sharma⁷, Subhash Varma⁷, Manish Modi⁸, Pallab Ray³, Megha Sharma³, M S Dhillion⁹, Akhilesh Pandey^{1

2

10

11

12

13}, Harsha Gowda¹, T S Keshava Prasad^{1

5}

Affiliations

¹ Institute of Bioinformatics, International Technology Park, Bangalore 560066, India.
² Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
³ Department of Medical Microbiology, PGIMER, Chandigarh 160012, India.
⁴ School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, Kerala 690525, India.
⁵ Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India.
⁶ School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India.
⁷ Department of Internal Medicine, PGIMER, Chandigarh 160012, India.
⁸ Department of Neurology, PGIMER, Chandigarh 160012, India.
⁹ Department of Orthopedics, PGIMER, Chandigarh 160012, India.
¹⁰ McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
¹¹ Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
¹² Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
¹³ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

This article describes the whole genome sequencing data from 5 extrapulmonary tuberculosis clinical isolates. The whole genome sequencing was carried out on Illumina MiSeq platform to identify single nucleotide variations (SNVs) associated with drug resistance. A total of 214 SNVs in the coding and promoter regions were identified in the whole genome sequencing analysis. Among the identified SNVs, 18 SNVs were identified in genes known to be associated with first and second line drug resistance. The data is related to the research article "Whole genome sequencing of Mycobacterium tuberculosis isolates from extrapulmonary sites" (Sharma et al., 2017) [1].