Bisphenol-A in breast adipose tissue of breast cancer cases and controls

Katherine W Reeves; Sallie Schneider; Jingchuan Xue; Kurunthachalam Kannan; Holly Mason; Melissa Johnson; Grace Makari-Judson; Mary Díaz Santana

doi:10.1016/j.envres.2018.08.033

Bisphenol-A in breast adipose tissue of breast cancer cases and controls

Environ Res. 2018 Nov:167:735-738. doi: 10.1016/j.envres.2018.08.033. Epub 2018 Aug 31.

Authors

Katherine W Reeves¹, Sallie Schneider², Jingchuan Xue³, Kurunthachalam Kannan³, Holly Mason⁴, Melissa Johnson⁵, Grace Makari-Judson⁶, Mary Díaz Santana⁷

Affiliations

¹ Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, 715 North Pleasant Street, Amherst, MA, United States. Electronic address: kwreeves@schoolph.umass.edu.
² Pioneer Valley Life Sciences Institute, Baystate Health, 3601 Main Street, Springfield, MA, United States.
³ Wadsworth Center, New York State Department of Health, and Department of Health Sciences, School of Public Health, State University of New York at Albany, 120 New Scotland Avenue, Albany, NY, United States.
⁴ Department of Surgery, Baystate Health, 759 Chestnut Street, Springfield, MA, United States.
⁵ Pioneer Valley Plastic Surgery, 100 Wason Avenue #360, Springfield, MA, United States.
⁶ Baystate Regional Cancer Program, 3350 Main Street, Springfield, MA, United States.
⁷ Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, 715 North Pleasant Street, Amherst, MA, United States.

PMID: 30236518
DOI: 10.1016/j.envres.2018.08.033

Abstract

We evaluated whether bisphenol-A (BPA) could be quantified in breast adipose tissue samples provided by 36 breast cancer mastectomy patients and 14 reduction mammoplasty patients. Samples of breast adipose tissue were collected and BPA concentration was quantified using HPLC-ESI-MS/MS. BPA was detectable above the limit of quantitation of 0.38 ng/g in 30.6% of samples. BPA concentrations varied within- and between breasts and were similar between cases and controls (0.39 vs 0.41 ng/g, p = 0.74).

Keywords: Adipose; Bisphenol-A; Breast; Cancer; Endocrine disruption.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / drug effects
Benzhydryl Compounds / toxicity*
Breast Neoplasms* / etiology
Chromatography, High Pressure Liquid
Humans
Mastectomy
Phenols / toxicity*
Tandem Mass Spectrometry

Substances

Benzhydryl Compounds
Phenols
bisphenol A