Passive functional mapping of receptive language areas using electrocorticographic signals

J R Swift; W G Coon; C Guger; P Brunner; M Bunch; T Lynch; B Frawley; A L Ritaccio; G Schalk

doi:10.1016/j.clinph.2018.09.007

Passive functional mapping of receptive language areas using electrocorticographic signals

Clin Neurophysiol. 2018 Dec;129(12):2517-2524. doi: 10.1016/j.clinph.2018.09.007. Epub 2018 Sep 25.

Authors

J R Swift¹, W G Coon², C Guger³, P Brunner⁴, M Bunch⁵, T Lynch⁶, B Frawley⁷, A L Ritaccio⁸, G Schalk⁹

Affiliations

¹ g.tec neurotechnology USA, Rensselaer, NY, USA; Dept. of Biomedical Sciences, State University of New York at Albany, Albany, NY, USA; National Ctr. for Adaptive Neurotechnologies, Wadsworth Center, NY State Dept. of Health, Albany, NY, USA. Electronic address: jswift@albany.edu.
² g.tec neurotechnology USA, Rensselaer, NY, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Dept. of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; National Ctr. for Adaptive Neurotechnologies, Wadsworth Center, NY State Dept. of Health, Albany, NY, USA. Electronic address: wcoon@mgh.harvard.edu.
³ g.tec neurotechnology USA, Rensselaer, NY, USA. Electronic address: guger@gtec.at.
⁴ Dept. of Neurology, Albany Medical College, Albany, NY, USA; National Ctr. for Adaptive Neurotechnologies, Wadsworth Center, NY State Dept. of Health, Albany, NY, USA. Electronic address: brunner@neurotechcenter.org.
⁵ Dept. of Neurology, Albany Medical College, Albany, NY, USA. Electronic address: BunchM@mail.amc.edu.
⁶ Dept. of Neurology, Albany Medical College, Albany, NY, USA. Electronic address: lyncht@mail.amc.edu.
⁷ Dept. of Neurology, Albany Medical College, Albany, NY, USA. Electronic address: FrawleBK@mail.amc.edu.
⁸ Dept. of Neurology, Mayo Clinic, Jacksonville, FL, USA; National Ctr. for Adaptive Neurotechnologies, Wadsworth Center, NY State Dept. of Health, Albany, NY, USA. Electronic address: ritaccio.anthony@mayo.edu.
⁹ Dept. of Biomedical Sciences, State University of New York at Albany, Albany, NY, USA; Dept. of Neurology, Albany Medical College, Albany, NY, USA; National Ctr. for Adaptive Neurotechnologies, Wadsworth Center, NY State Dept. of Health, Albany, NY, USA. Electronic address: gschalk@neurotechcenter.org.

Abstract

Objective: To validate the use of passive functional mapping using electrocorticographic (ECoG) broadband gamma signals for identifying receptive language cortex.

Methods: We mapped language function in 23 patients using ECoG and using electrical cortical stimulation (ECS) in a subset of 15 subjects.

Results: The qualitative comparison between cortical sites identified by ECoG and ECS show a high concordance. A quantitative comparison indicates a high level of sensitivity (95%) and a lower level of specificity (59%). Detailed analysis reveals that 82% of all cortical sites identified by ECoG were within one contact of a site identified by ECS.

Conclusions: These results show that passive functional mapping reliably localizes receptive language areas, and that there is a substantial concordance between the ECoG- and ECS-based methods. They also point to a more refined understanding of the differences between ECoG- and ECS-based mappings. This refined understanding helps to clarify the instances in which the two methods disagree and can explain why neurosurgical practice has established the concept of a "safety margin."

Significance: Passive functional mapping using ECoG signals provides a fast, robust, and reliable method for identifying receptive language areas without many of the risks and limitations associated with ECS.

Keywords: ECoG; Electrocorticography; Functional mapping; Intracranial; Receptive language.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Validation Study

MeSH terms

Adolescent
Adult
Cerebral Cortex / physiology*
Electrocorticography / methods*
Female
Gamma Rhythm
Humans
Language*
Male
Middle Aged

Abstract

Publication types

MeSH terms

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