Safe CRISPR: Challenges and Possible Solutions

Michael Pineda; Ashley Lear; James P Collins; Samira Kiani

doi:10.1016/j.tibtech.2018.09.010

Safe CRISPR: Challenges and Possible Solutions

Trends Biotechnol. 2019 Apr;37(4):389-401. doi: 10.1016/j.tibtech.2018.09.010. Epub 2018 Oct 21.

Authors

Michael Pineda¹, Ashley Lear¹, James P Collins², Samira Kiani³

Affiliations

¹ School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
² School of Life Sciences, Arizona State University, Tempe, AZ, USA. Electronic address: jcollins@asu.edu.
³ School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA; www.kianilab.com. Electronic address: samira.kiani@asu.edu.

PMID: 30352704
DOI: 10.1016/j.tibtech.2018.09.010

Abstract

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

Keywords: CRISPR; biosafety; gene drives; gene therapies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomedical Research / trends
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Editing*
Genetic Therapy / adverse effects
Genetic Therapy / methods*
Humans
Molecular Targeted Therapy / adverse effects
Molecular Targeted Therapy / methods*

Grants and funding

R01 EB024562/EB/NIBIB NIH HHS/United States