Abstract
Dopaminergic agents including both levodopa and direct-acting agonists induce a variety psychiatric side-effects of which psychosis is the most significant. When this occurs early in the course of treatment, there is usually a history of prior psychotic illness. Chronic treatment can, however, elicit psychosis in individuals without such a history. The possible pathogenesis of this is reviewed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Dreams
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Dyskinesia, Drug-Induced / drug therapy
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Hallucinations / chemically induced
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Humans
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Levodopa / adverse effects*
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Mental Disorders / chemically induced*
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Mental Disorders / psychology
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Paranoid Disorders / chemically induced
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Parkinson Disease / drug therapy*
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Parkinson Disease / physiopathology
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Serotonin / physiology
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Severity of Illness Index
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Sleep Wake Disorders / chemically induced