Abstract
Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.
MeSH terms
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Antioxidants / toxicity
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Biomimetic Materials / chemical synthesis
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Biomimetic Materials / chemistry
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Biomimetic Materials / pharmacology*
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Biomimetic Materials / toxicity
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Carbon / chemistry
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Catalase / chemistry
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HeLa Cells
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Humans
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Hydrogen Peroxide / chemistry
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Hydrogen Peroxide / metabolism
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Iron / chemistry*
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Nanocomposites / chemistry*
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Nanocomposites / toxicity
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Nanoparticles / chemistry
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Nanoparticles / toxicity
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Nitrogen / chemistry*
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Oxidative Stress / drug effects
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Porosity
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Superoxide Dismutase / chemistry
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Superoxides / chemistry
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Superoxides / metabolism
Substances
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Antioxidants
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Superoxides
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Carbon
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Hydrogen Peroxide
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Iron
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Catalase
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Superoxide Dismutase
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Nitrogen