A single-atom Fe-N4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Chem Commun (Camb). 2018 Dec 20;55(2):159-162. doi: 10.1039/c8cc08116f.

Abstract

Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

MeSH terms

  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Antioxidants / toxicity
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology*
  • Biomimetic Materials / toxicity
  • Carbon / chemistry
  • Catalase / chemistry
  • HeLa Cells
  • Humans
  • Hydrogen Peroxide / chemistry
  • Hydrogen Peroxide / metabolism
  • Iron / chemistry*
  • Nanocomposites / chemistry*
  • Nanocomposites / toxicity
  • Nanoparticles / chemistry
  • Nanoparticles / toxicity
  • Nitrogen / chemistry*
  • Oxidative Stress / drug effects
  • Porosity
  • Superoxide Dismutase / chemistry
  • Superoxides / chemistry
  • Superoxides / metabolism

Substances

  • Antioxidants
  • Superoxides
  • Carbon
  • Hydrogen Peroxide
  • Iron
  • Catalase
  • Superoxide Dismutase
  • Nitrogen