NLRC3 Restrains Responses to a T

Caroline L Holley; Rebecca C Coll; Kate Schroder

doi:10.1016/j.immuni.2018.12.003

NLRC3 Restrains Responses to a T

Immunity. 2018 Dec 18;49(6):989-991. doi: 10.1016/j.immuni.2018.12.003.

Authors

Caroline L Holley¹, Rebecca C Coll¹, Kate Schroder²

Affiliations

¹ Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, University of Queensland, St. Lucia, QLD, Australia.
² Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, University of Queensland, St. Lucia, QLD, Australia. Electronic address: k.schroder@imb.uq.edu.au.

PMID: 30566886
DOI: 10.1016/j.immuni.2018.12.003

Abstract

The NOD-like receptor protein NLRC3 attenuates myeloid cell inflammatory responses. In this issue of Immunity, Uchimura et al. (2018) reveal additional T-cell-intrinsic functions for NLRC3 in restricting T cell metabolism, T helper 1 and T helper 17 cell responses, and antiviral and autoimmune responses.

Publication types

Comment

MeSH terms

Autoimmunity*
Carrier Proteins
Immunity, Innate
Intercellular Signaling Peptides and Proteins*
T-Lymphocytes

Substances

Carrier Proteins
Intercellular Signaling Peptides and Proteins