Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes

Ahmed M Naglah; Mohamed A Al-Omar; Atef Kalmouch; Amnah Ma Alsuhaibani; Akram M El-Didamony; Nader Hassan; Sameh Abo Taleb; Moamen S Refat; Abdulrahman A Almehizia; Mashooq A Bhat; Nasser S Al-Shakliah; Jehan Y Al-Humaidi; Asma S Al-Wasidi

doi:10.4155/fmc-2018-0471

Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes

Future Med Chem. 2019 Feb;11(3):193-210. doi: 10.4155/fmc-2018-0471. Epub 2019 Jan 15.

Authors

Affiliations

¹ Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
² Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt.
³ Nutrition & Food Sciences Department, Home Economic College, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
⁴ Department of Chemistry, Faculty of Science, Zagazig University, Egypt.
⁵ Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt.
⁶ Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.
⁷ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
⁸ Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

PMID: 30642200
DOI: 10.4155/fmc-2018-0471

Abstract

Aim: This research paper is aimed at designing a novel insulin alternative for the treatment of diabetes. Materials & methods: Six novel vanadyl(II) compounds, [(AMP^-2)(VO⁺²)(AA _n ^-1)]·NH₄ ⁺¹, were synthesized from an equimolar ratio of adenosine monophosphate, VOSO₄ and amino acids (AA _n ). Results: The magnetic moments and electronic spectra revealed the square pyramidal geometrical structure of the complexes. In an in vivo study, the insulin levels, blood glucose levels, lipid profiles and histology of the pancreas and liver of the animals treated with the complexes were similar to those of healthy control animals, unlike the untreated and vanadyl sulfate(II)-treated diabetic ones. Conclusion: The data gathered in the current research illustrated that vanadyl(II)-AMP-amino acid (AA) mixed-ligand complexes can function as antidiabetic agents.

Keywords: VO2+ ion; adenosine monophosphate; amino acid; diabetes; insulin alternative; vanadium; vanadyl(II).