Endoplasmic reticulum stress: a key player in human disease

FEBS J. 2019 Jan;286(2):228-231. doi: 10.1111/febs.14740.

Abstract

This Special Issue comprises eleven excellent reviews that illustrate the role of ER stress in different human diseases, including myopathies and lung diseases, as well as in modulating liver dysfunction and inflammatory responses. These reviews also highlight the function of the UPR in neurodegenerative disorders and cancer, while discussing the potential benefits of targeting the UPR as a therapeutic approach. We hope you find these reviews interesting and informative and we thank the authors for these excellent contributions.

Keywords: ER stress; disease; unfolded protein response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Endoplasmic Reticulum / metabolism
  • Endoplasmic Reticulum / pathology*
  • Endoplasmic Reticulum Stress*
  • Humans
  • Muscular Diseases / metabolism
  • Muscular Diseases / pathology*
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology*
  • Unfolded Protein Response*