Allergen-specific CD8+ T cells in peanut-allergic individuals

Wong Yu; Xiaoying Zhou; Diane Dunham; Shu Chen Lyu; Monali Manohar; Wenming Zhang; Fan Zhao; Mark M Davis; Kari Nadeau

doi:10.1016/j.jaci.2019.01.011

Allergen-specific CD8⁺ T cells in peanut-allergic individuals

J Allergy Clin Immunol. 2019 May;143(5):1948-1952. doi: 10.1016/j.jaci.2019.01.011. Epub 2019 Jan 22.

Authors

Wong Yu¹, Xiaoying Zhou², Diane Dunham², Shu Chen Lyu², Monali Manohar², Wenming Zhang², Fan Zhao³, Mark M Davis⁴, Kari Nadeau⁵

Affiliations

¹ Sean N. Parker Center for Allergy and Asthma Research at Stanford University School of Medicine, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, Calif; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University, Stanford, Calif.
² Sean N. Parker Center for Allergy and Asthma Research at Stanford University School of Medicine, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, Calif.
³ Department of Microbiology and Immunology, Stanford University, Stanford, Calif.
⁴ Department of Microbiology and Immunology, Stanford University, Stanford, Calif; Institute of Immunity, Transplantation and Infection, Stanford University, Stanford, Calif; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, Calif.
⁵ Sean N. Parker Center for Allergy and Asthma Research at Stanford University School of Medicine, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, Calif; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Stanford University, Stanford, Calif. Electronic address: knadeau@stanford.edu.

Abstract

CD8⁺ T cells are seldom considered in IgE mediated food allergy; we show that peanut specific CD8⁺ T cells are increased in peanut allergic human subjects.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Allergens / immunology*
Arachis / immunology*
CD8-Positive T-Lymphocytes / immunology*
Child
Child, Preschool
Female
Humans
Immunoglobulin E / immunology
Male
Middle Aged
Peanut Hypersensitivity / immunology*
Peptides / immunology*
Plant Proteins / immunology*
Young Adult

Substances

Allergens
Peptides
Plant Proteins
Immunoglobulin E

Abstract

Publication types

MeSH terms

Substances

Grants and funding