From bench to bedside: Current developments and future possibilities of artificial human ovary to restore fertility

Mahmoud Salama; Teresa K Woodruff

doi:10.1111/aogs.13552

From bench to bedside: Current developments and future possibilities of artificial human ovary to restore fertility

Acta Obstet Gynecol Scand. 2019 May;98(5):659-664. doi: 10.1111/aogs.13552. Epub 2019 Feb 24.

Authors

Mahmoud Salama¹, Teresa K Woodruff¹

Affiliation

¹ Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

PMID: 30714119
DOI: 10.1111/aogs.13552

Abstract

Several fertility restoration options are not feasible for some cancer patients, poor responders and patients with premature ovarian failure who have diminished ovarian reserve. To preserve and restore fertility in such patients, new strategies should be offered including artificial human ovary technology. In this mini-review, we explore from bench to bedside the current developments and future possibilities of artificial human ovary technology to restore fertility.

Keywords: artificial ovary; cancer patients; fertility restoration; oncofertility; poor responders; premature ovarian failure.

Publication types

Review

MeSH terms

Artificial Organs*
Female
Fertility Preservation* / methods
Fertility Preservation* / trends
Humans
Infertility, Female* / chemically induced
Infertility, Female* / therapy
Inventions
Ovary*
Primary Ovarian Insufficiency / therapy*
Translational Research, Biomedical