Imaging Cancer Metabolism with Positron Emission Tomography (PET)

Methods Mol Biol. 2019:1928:29-44. doi: 10.1007/978-1-4939-9027-6_2.

Abstract

Positron emission tomography (PET) enables the noninvasive spatiotemporal analysis of cancer metabolism in vivo. Both natural and nonnatural PET tracers have been developed to assess metabolic pathways during tumorigenesis, cancer progression, and metastasis. Here we describe the dynamic in vivo PET/CT imaging of the glucose analogue [18F]fluoro-2-deoxy-D-glucose (FDG), taking into consideration the methodology for alternative metabolic PET substrates.

Keywords: Carbon-11; FDG; Fluorine-18; Fluorodeoxyglucose; Imaging; Mouse; PET; Positron emission tomography.

MeSH terms

  • Animals
  • Biomarkers
  • Carbon Radioisotopes
  • Disease Models, Animal
  • Energy Metabolism*
  • Fluorodeoxyglucose F18
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Metabolic Networks and Pathways
  • Mice
  • Neoplasms / diagnostic imaging*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography* / methods
  • Radiopharmaceuticals

Substances

  • Biomarkers
  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18