High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

Nicklas Brustad; Anders U Eliasen; Jakob Stokholm; Klaus Bønnelykke; Hans Bisgaard; Bo L Chawes

doi:10.1001/jama.2019.0052

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

JAMA. 2019 Mar 12;321(10):1003-1005. doi: 10.1001/jama.2019.0052.

Authors

Nicklas Brustad¹, Anders U Eliasen¹, Jakob Stokholm¹, Klaus Bønnelykke¹, Hans Bisgaard¹, Bo L Chawes¹

Affiliation

¹ Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte University Hospital, Copenhagen, Denmark.

Abstract

This long-term follow-up of a randomized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplementation on wheezing in children at the age of 3 years extends the findings an additional 3 years and describes asthma risk at the age of 6 years.

Publication types

Randomized Controlled Trial

MeSH terms

Asthma / diagnosis
Asthma / epidemiology
Asthma / prevention & control*
Child
Child, Preschool
Dietary Supplements*
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Male
Pregnancy
Prevalence
Regression Analysis
Respiratory Function Tests
Respiratory Sounds
Vitamin D / administration & dosage*
Vitamins / administration & dosage*

Substances

Vitamins
Vitamin D