Abstract
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Autoimmune Diseases / immunology*
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CD4-Positive T-Lymphocytes / immunology*
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Celiac Disease / classification
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Celiac Disease / immunology*
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Glutens / immunology
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HLA-DQ Antigens / immunology
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Humans
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Immunophenotyping
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Intestines / immunology
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Lupus Erythematosus, Systemic / immunology
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Scleroderma, Systemic / immunology
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T-Lymphocyte Subsets / classification
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T-Lymphocyte Subsets / immunology