Barberry (Berberis vulgaris L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials

Amir Hadi; Arman Arab; Ehsan Ghaedi; Nahid Rafie; Maryam Miraghajani; Marzieh Kafeshani

doi:10.1016/j.ctim.2019.01.017

Barberry (Berberis vulgaris L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials

Complement Ther Med. 2019 Apr:43:117-124. doi: 10.1016/j.ctim.2019.01.017. Epub 2019 Jan 24.

Authors

Amir Hadi¹, Arman Arab², Ehsan Ghaedi³, Nahid Rafie⁴, Maryam Miraghajani⁵, Marzieh Kafeshani⁶

Affiliations

¹ Halal Research Center of IRI, FDA, Tehran, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Department of Cellular and molecular Nutrition, School of Nutritional sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
⁴ Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK. Electronic address: Ms.miraghajani@yahoo.com.
⁶ School of Nutrition and Food Sciences, Food Security and Nutrition Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Marzikafeshani@hlth.mui.ac.ir.

PMID: 30935518
DOI: 10.1016/j.ctim.2019.01.017

Abstract

Objective: We performed a meta-analysis to evaluate the efficacy of barberry supplementation on plasma lipid concentration in adult population.

Methods: The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to October 2018) to identify randomized controlled trials (RCTs) investigating the effects of barberry supplementation on serum lipid parameters. Mean Difference (MD) was pooled using a random-effects model.

Results: Meta-analysis on 5 RCTs with 339 participants indicated that barberry supplementation significantly decreased the levels of total cholesterol (MD: -23.58 mg/dl, 95% CI: -31.00 to -16.16, P ≤ 0.001), triglyceride (MD: -29.16 mg/dl, 95% CI: -42.91 to -15.41, P ≤ 0.001), and low-density lipoprotein cholesterol (MD: -13.75 mg/dl, 95% CI: -19.31 to -8.20, P ≤ 0.001) whereas changes in high-density lipoprotein cholesterol (MD: 3.40 mg/dl, 95% CI: -0.06-6.87, P = 0.054) was not statistically significant.

Conclusion: This systematic review and meta-analysis suggested the efficacy of barberry supplementation on lipid parameters. However, further large-scale studies are needed to confirm these results.

Keywords: Barberry; Lipids; Meta-analysis; Randomized controlled trials.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Berberis / chemistry*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Dietary Supplements
Humans
Lipids / blood*
Plant Preparations / therapeutic use*
Randomized Controlled Trials as Topic
Triglycerides / blood

Substances

Cholesterol, HDL
Cholesterol, LDL
Lipids
Plant Preparations
Triglycerides