The role of orthosilicic acid-induced autophagy on promoting differentiation and mineralization of osteoblastic cells

J Biomater Appl. 2019 Jul;34(1):94-103. doi: 10.1177/0885328219837700. Epub 2019 Apr 8.

Authors

Affiliations

¹ 1 Department of Orthopedics, Qilu Hospital of Shandong University and Shandong University Spine and Spine Cord Disease Research Center, Shandong Province, China.
² 2 Department of Spinal Surgery, the Affilated Hospital of Qingdao University, Shandong Province, China.

PMID: 30961431
DOI: 10.1177/0885328219837700

No abstract available

Keywords: Osteoporosis; autophagy; bone mineral density; orthosilicic acid; osteogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Adenine / chemistry
Alkaline Phosphatase / metabolism
Animals
Antigens, Tumor-Associated, Carbohydrate / metabolism
Autophagy / drug effects*
Bone Density / drug effects
Calcification, Physiologic / drug effects
Cell Differentiation / drug effects*
Cell Line
Collagen / chemistry
Core Binding Factor Alpha 2 Subunit / metabolism
Female
Glycoproteins / metabolism
Humans
Mice
Microtubule-Associated Proteins / metabolism
Models, Animal
Osteoblasts / cytology
Osteogenesis
RNA-Binding Proteins / drug effects*
RNA-Binding Proteins / genetics
Rats, Wistar
Sequestosome-1 Protein / drug effects*
Sequestosome-1 Protein / genetics
Silicic Acid / chemistry*

Substances

Antigens, Tumor-Associated, Carbohydrate
Core Binding Factor Alpha 2 Subunit
Glycoproteins
Microtubule-Associated Proteins
OVX1 antigen
P62 protein, human
RNA-Binding Proteins
SQSTM1 protein, human
Sequestosome-1 Protein
Silicic Acid
3-methyladenine
Collagen
Alkaline Phosphatase
Adenine