Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1

Terje Johansen

doi:10.1016/j.cub.2019.03.008

Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1

Curr Biol. 2019 Apr 22;29(8):R297-R299. doi: 10.1016/j.cub.2019.03.008.

Author

Terje Johansen¹

Affiliation

¹ Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway. Electronic address: terje.johansen@uit.no.

PMID: 31014491
DOI: 10.1016/j.cub.2019.03.008

Abstract

A new study shows that the oligomerization of p62/Sequestosome-1 (SQSTM1) - a selective autophagy receptor and signaling adapter - is regulated directly by vault RNA. This riboregulation negatively affects the aggregation state of p62 and thereby its autophagic degradation and its role as a selective autophagy receptor.

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MeSH terms

Autophagy*
RNA*
RNA, Bacterial
Sequestosome-1 Protein
Signal Transduction

Substances

RNA I
RNA, Bacterial
Sequestosome-1 Protein
RNA