Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

R L Neve; P Harris; K S Kosik; D M Kurnit; T A Donlon

doi:10.1016/0169-328x(86)90033-1

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Brain Res. 1986 Dec;387(3):271-80. doi: 10.1016/0169-328x(86)90033-1.

Authors

R L Neve, P Harris, K S Kosik, D M Kurnit, T A Donlon

PMID: 3103857
DOI: 10.1016/0169-328x(86)90033-1

Abstract

We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 2*
DNA / isolation & purification*
Gene Expression Regulation
Humans
Microtubule-Associated Proteins / biosynthesis
Microtubule-Associated Proteins / genetics*
Nucleic Acid Hybridization
tau Proteins

Substances

Microtubule-Associated Proteins
tau Proteins
DNA

Grants and funding

etc