The importance of methionine metabolism

Elife. 2019 May 2:8:e47221. doi: 10.7554/eLife.47221.

Abstract

T helper cells import the amino acid methionine to synthesize new proteins and to provide the methyl groups needed for the methylation of RNA and DNA that drives T cell proliferation and differentiation.

Keywords: T cell activation; immunology; inflammation; lymphocyte; methionine metabolism; mouse; nutrient uptake.

MeSH terms

  • Animals
  • Humans
  • Interleukin-12 / metabolism
  • Methionine / metabolism*
  • Models, Biological
  • T-Lymphocytes / metabolism

Substances

  • Interleukin-12
  • Methionine