Activation of complement and coagulation in juvenile dermatomyositis

Arthritis Rheum. 1987 May;30(5):572-6. doi: 10.1002/art.1780300513.

Abstract

In patients with juvenile dermatomyositis (JDM), small vessel occlusion and thrombosis result in a decrease in the capillary: muscle fiber ratio. We studied 15 patients with JDM. Six of 7 patients with clinically active JDM had elevated levels of C3d. Moreover, concentrations of fibrinopeptide A and factor VIII-related antigen were significantly increased in patients with clinically active JDM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens / analysis
  • Blood Coagulation*
  • Child
  • Child, Preschool
  • Complement C3 / analysis*
  • Complement C3d
  • Dermatomyositis / blood
  • Dermatomyositis / immunology*
  • Factor VIII / analysis
  • Factor VIII / immunology
  • Female
  • Fibrinopeptide A / analysis
  • Humans
  • Male
  • von Willebrand Factor

Substances

  • Antigens
  • Complement C3
  • von Willebrand Factor
  • Fibrinopeptide A
  • Complement C3d
  • Factor VIII