Abstract
In patients with juvenile dermatomyositis (JDM), small vessel occlusion and thrombosis result in a decrease in the capillary: muscle fiber ratio. We studied 15 patients with JDM. Six of 7 patients with clinically active JDM had elevated levels of C3d. Moreover, concentrations of fibrinopeptide A and factor VIII-related antigen were significantly increased in patients with clinically active JDM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antigens / analysis
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Blood Coagulation*
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Child
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Child, Preschool
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Complement C3 / analysis*
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Complement C3d
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Dermatomyositis / blood
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Dermatomyositis / immunology*
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Factor VIII / analysis
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Factor VIII / immunology
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Female
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Fibrinopeptide A / analysis
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Humans
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Male
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von Willebrand Factor
Substances
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Antigens
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Complement C3
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von Willebrand Factor
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Fibrinopeptide A
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Complement C3d
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Factor VIII