Autophagy Keeps the Balance in Tissue Homeostasis

Michael Buszczak; Helmut Krämer

doi:10.1016/j.devcel.2019.05.005

Autophagy Keeps the Balance in Tissue Homeostasis

Dev Cell. 2019 May 20;49(4):499-500. doi: 10.1016/j.devcel.2019.05.005.

Authors

Michael Buszczak¹, Helmut Krämer²

Affiliations

¹ Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: michael.buszczak@utsouthwestern.edu.
² Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA; Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: helmut.kramer@utsouthwestern.edu.

PMID: 31112694
DOI: 10.1016/j.devcel.2019.05.005

Abstract

Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of Developmental Cell, Zhang and colleagues (2019) show autophagy-mediated regulation of EGFR signaling cell autonomously controls intestinal stem cell proliferation, with implications for human colorectal cancer development.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Autophagy*
Cell Differentiation
Cell Proliferation
ErbB Receptors
Homeostasis
Humans
Stem Cells

Substances

EGFR protein, human
ErbB Receptors

Abstract

Publication types

MeSH terms

Substances

Grants and funding