Abstract
In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antigens, Surface / genetics
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Antigens, Surface / immunology*
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H-2 Antigens / immunology
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Hybridomas / immunology
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Immune Tolerance*
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Major Histocompatibility Complex*
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Mice
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Mice, Inbred Strains
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Minor Lymphocyte Stimulatory Antigens
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocytes / immunology*
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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H-2 Antigens
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Minor Lymphocyte Stimulatory Antigens
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Receptors, Antigen, T-Cell