Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

Nature. 1988 Mar 3;332(6159):35-40. doi: 10.1038/332035a0.

Abstract

In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antigens, Surface / genetics
  • Antigens, Surface / immunology*
  • H-2 Antigens / immunology
  • Hybridomas / immunology
  • Immune Tolerance*
  • Major Histocompatibility Complex*
  • Mice
  • Mice, Inbred Strains
  • Minor Lymphocyte Stimulatory Antigens
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • H-2 Antigens
  • Minor Lymphocyte Stimulatory Antigens
  • Receptors, Antigen, T-Cell