Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Drug Des Devel Ther. 2019 Jul 3:13:2145-2152. doi: 10.2147/DDDT.S202410. eCollection 2019.

Abstract

Objective: To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery.

Methods: A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery.

Results: VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03±4.38 mg vs 24.43±4.94) and 48 hrs (52.23±9.57 mg vs 44.20±10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO2 were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group.

Conclusion: Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.

Keywords: celecoxib; lumbar spine surgery; preemptive analgesia; pregabalin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Analgesics / administration & dosage
  • Analgesics / therapeutic use*
  • Celecoxib / administration & dosage
  • Celecoxib / therapeutic use*
  • Female
  • Humans
  • Lumbar Vertebrae / surgery*
  • Male
  • Middle Aged
  • Morphine / administration & dosage
  • Morphine / therapeutic use
  • Pregabalin / administration & dosage
  • Pregabalin / therapeutic use*
  • Prospective Studies

Substances

  • Analgesics
  • Pregabalin
  • Morphine
  • Celecoxib