Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations

Liis Uusküla-Reimand; Michael D Wilson

doi:10.1016/j.molcel.2019.07.003

Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations

Mol Cell. 2019 Jul 25;75(2):203-205. doi: 10.1016/j.molcel.2019.07.003.

Authors

Liis Uusküla-Reimand¹, Michael D Wilson²

Affiliations

¹ Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada.
² Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: michael.wilson@sickkids.ca.

PMID: 31348877
DOI: 10.1016/j.molcel.2019.07.003

Abstract

In this issue of Molecular Cell, Gothe, Maman et al. and Canela et al. demonstrate that type II topoisomerase (TOP2B/TOP2A)-mediated DNA breaks, and the oncogenic translocations they generate, are dependent on transcription and governed by chromatin architecture.

Publication types

Comment

MeSH terms

Chromatin
Chromosomes
DNA
DNA Damage
DNA Topoisomerases, Type II / genetics*
DNA-Binding Proteins / genetics*

Substances

Chromatin
DNA-Binding Proteins
DNA
DNA Topoisomerases, Type II