Microbiome-focused asthma management strategies

Shakti D Shukla; Madhur D Shastri; Wai Chin Chong; Kamal Dua; Kurtis F Budden; Malik Quasir Mahmood; Nicole G Hansbro; Simon Keely; Rajaraman Eri; Rahul P Patel; Gregory M Peterson; Philip M Hansbro

doi:10.1016/j.coph.2019.06.003

Microbiome-focused asthma management strategies

Curr Opin Pharmacol. 2019 Jun:46:143-149. doi: 10.1016/j.coph.2019.06.003. Epub 2019 Jul 26.

Authors

Affiliations

¹ Priority Research Centre for Healthy Lungs, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute & University of Newcastle, Callaghan, NSW, Australia.
² School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.
³ Department of Molecular and Translational Science, Monash University, Clayton, Australia; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Australia.
⁴ Priority Research Centre for Healthy Lungs, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute & University of Newcastle, Callaghan, NSW, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia.
⁵ Medicine, College of Health and Medicine, University of Tasmania, Hobart, Australia.
⁶ Priority Research Centre for Healthy Lungs, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute & University of Newcastle, Callaghan, NSW, Australia; Centre for inflammation, Centenary Institute, Sydney, and School of Life Sciences, University of Technology, Ultimo, NSW, Australia.
⁷ Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, Australia.
⁸ Priority Research Centre for Healthy Lungs, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute & University of Newcastle, Callaghan, NSW, Australia; Centre for inflammation, Centenary Institute, Sydney, and School of Life Sciences, University of Technology, Ultimo, NSW, Australia. Electronic address: p.hansbro@centenary.org.au.

PMID: 31357048
DOI: 10.1016/j.coph.2019.06.003

Abstract

Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The role of microbiomes, particularly in chronic diseases has generated considerable interest in recent times. Existing evidence clearly demonstrates an association between asthma initiation and the microbiome, both respiratory and gastro-intestinal, although its' roles are poorly understood when assessing the asthma progression or heterogeneity (i.e. phenotypes/endotypes) across different geographical locations. Moreover, modulating microbiomes could be preventive and/or therapeutic in patients with asthma warrants urgent attention. Here, we review recent advances in assessing the role of microbiomes in asthma and present the challenges associated with the potential therapeutic utility of modifying microbiomes in management.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Asthma / microbiology*
Asthma / therapy*
Humans
Intestines / microbiology
Lung / microbiology
Microbiota*