Abstract
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.
MeSH terms
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Animals
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Cattle
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Dinitrochlorobenzene / pharmacology
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Furans*
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Glutathione Transferase / antagonists & inhibitors*
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Humans
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Indican / pharmacology
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Indoleacetic Acids / pharmacology
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Liver / enzymology*
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Propionates / blood*
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Protein Binding
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Rats
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Serum Albumin / metabolism
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Uremia / blood*
Substances
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Dinitrochlorobenzene
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Furans
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Indoleacetic Acids
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Propionates
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Serum Albumin
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indoleacetic acid
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3-carboxy-4-methyl-5-propyl-2-furanpropionic acid
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Glutathione Transferase
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Indican