Reconstitution of Organismal Liver Clock Function Requires Light

Takahito Miyake; Masao Doi

doi:10.1016/j.tem.2019.07.017

Reconstitution of Organismal Liver Clock Function Requires Light

Trends Endocrinol Metab. 2019 Sep;30(9):569-571. doi: 10.1016/j.tem.2019.07.017. Epub 2019 Jul 31.

Authors

Takahito Miyake¹, Masao Doi²

Affiliations

¹ Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan.
² Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan. Electronic address: doimasao@pharm.kyoto-u.ac.jp.

PMID: 31375394
DOI: 10.1016/j.tem.2019.07.017

Abstract

Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo. This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.

Keywords: Bmal1; autonomy; circadian; diurnal physiology; light; liver metabolism; systemic signaling.

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MeSH terms

Animals
Circadian Clocks*
Circadian Rhythm
Liver
Mice
Photoperiod