An intermediate purity concentrate of factor VIII, treated with solvent and detergent (SD), was successfully used for treatment of intracerebral hematoma in a newborn with type III von Willebrand's disease. At the present time, the SD process used for the preparation of this factor VIII concentrate seems to be one of the most effective methods for viral inactivation. In this product, the biological properties of factor VIII and von Willebrand factor are preserved. Thus, the intermediate purity factor VIII SD concentrate could be used instead of frozen cryoprecipitate, as a safer therapy in the treatment of von Willebrand's disease.