Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

Cell Metab. 2020 Jan 7;31(1):18-25. doi: 10.1016/j.cmet.2019.09.010. Epub 2019 Oct 10.

Abstract

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

Keywords: metabolism; regulatory T cells; tissue homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity*
  • Animals
  • Autoimmunity*
  • Forkhead Transcription Factors / metabolism*
  • Homeostasis / immunology
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / physiopathology*
  • Regeneration / immunology
  • Regeneration / physiology
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors